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Aktuálně z laboratoře

O nás

Laboratoř farmakogenomiky (viz. Tým) se zabývá zejména hledáním vhodných prognostických a prediktivních biomarkerů pro hodnocení přežívání a odpovědi nádorových pacientů na terapii. Ve vlastním výzkumu využíváme genomické, epigenomické, proteomické a metabolomické přístupy k hodnocení biomarkerů v tkáňových preparátech pacientů dodaných klinickými pracovišti z celé republiky. Hlavní využití prediktivních biomarkerů vidíme v oblasti stratifikace pacientů do jednotlivých léčebných režimů. Nalezení a validace prognostických biomarkerů rovněž může přispět k vývoji terapeutik pro cílenou léčbu. Naše excelence spočívá ve více než dvacetileté zkušenosti v této oblasti podložené řadou řešených projektů včetně Centra excellence GA ČR a národních iniciativ NCLG a NUVR (viz. Projekty), v publikovaných odborných pracech (viz. Publikace) a v široké mezinárodní spolupráci (viz. Spolupráce). Jsme zakládajícími členy konsorcia PANDoRA (pandoraconsortium.wixsite.com), zabývajícího se výzkumem onemocnění slinivky břišní, a členy konsorcia ENOR (www.oxysterols.net), které se věnuje výzkumu významu oxysterolů.

Kromě řady domácích klinických i akademických pracovišť úzce spolupracujeme s Laboratoří translační genomiky nádorových onemocnění a Laboratoří nádorové léčby a regenerace tkáně

Tým

  • Prof. RNDr. Pavel Souček, CSc. – Vedoucí laboratoře
  • RNDr. Mgr. Radka Václavíková, Ph.D.
  • doc. RNDr. Pavel Dvořák, Ph.D.
  • Mgr. Veronika Boušková, Ph.D.
  • Mgr. Viktor Hlaváč, Ph.D.
  • Ing. Marie Ehrlichová
  • Ing. Simona Šůsová
  • Mgr. Alžběta Spálenková, Ph.D.
  • Mgr. Karolína Šeborová, Ph.D.
  • Mgr. Petr Holý, Ph.D.
  • Mgr. Tereza Tesařová
  • Ing. Lucie Heczko
  • Bhavana Hemantha Rao, MSc.
  • Mohammad Moufaq Khatar Al Obeed Allah, M.D.

Publikace

Nedávné – 2025-2023
  • Boušková V, Ehrlichová M, Spálenková A, Krus I, Šůsová S, Hlaváč V, Němcová V, Koževnikovová R, Trnková M, Vrána D, Gatěk J, Kopečková K, Mrhalová M, Měšťáková S, Souček P. Integrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes. Mol Oncol. 2025; in press. IF2023 = 5.0
  • Daniel N, Farinella R, Belluomini F, Fajkic A, Rizzato C, Souček P, Campa D, Hughes DJ. The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer. Semin Cancer Biol. 2025; 112: 43-57. doi: 10.1016/j.semcancer.2025.03.002. IF2023 = 12.1
  • Gayibov E, Sychra T, Souček P, Oliverius M. A current knowledge of the undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a narrative review. J Gastrointest Oncol 2025; 16(1):281-291. doi: 10.21037/jgo-24-780. IF2023 = 2.0
  • Gayibov E, Sychra T, Spálenková A, Souček P, Oliverius M. The use of patient-derived xenografts and patient-derived organoids in the search for new therapeutic regimens for pancreatic carcinoma. A review. Biomed Pharmacother 2025; 182:117750. doi: 10.1016/j.biopha.2024.117750. IF2023 = 6.1
  • Gálvez-Montosa F, Peduzzi G, Sanchez-Maldonado JM, Ter Horst R, Cabrera-Serrano AJ, Gentiluomo M, Macauda A, Luque N, Ünal P, García-Verdejo FJ, Li Y, López López JA, Stein A, Bueno-de-Mesquita HB, Arcidiacono PG, Zanette DL, Kahlert C, Perri F, Soucek P, Talar-Wojnarowska R, Theodoropoulos GE, Izbicki JR, Tamás H, Van Laarhoven H, Nappo G, Petrone MC, Lovecek M, Vermeulen RCH, Adamonis K, Reyes-Zurita FJ, Holleczek B, Sumskiene J, Mohelníková-Duchoňová B, Lawlor RT, Pezzilli R, Aoki MN, Pasquali C, Petrenkiene V, Basso D, Bunduc S, Comandatore A, Brenner H, Ermini S, Vanella G, Goetz MR, Archibugi L, Lucchesi M, Uzunoglu FG, Busch O, Milanetto AC, Puzzono M, Kupcinskas J, Morelli L, Sperti C, Carrara S, Capurso G, van Eijck CHJ, Oliverius M, Roth S, Tavano F, Kaaks R, Szentesi A, Vodickova L, Luchini C, Schöttker B, Landi S, Dohan O, Tacelli M, Greenhalf W, Gazouli M, Neoptolemos JP, Cavestro GM, Boggi U, Latiano A, Hegyi P, Ginocchi L, Netea MG, Sánchez-Rovira P, Canzian F, Campa D, Sainz J. Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization. Int J Cancer. 2025;156(2):339-352. doi: 10.1002/ijc.35196. IF2023 = 5.7
  • Kováčová M, Hlaváč V, Koževnikovová R, Rauš K, Gatěk J, Souček P. Artificial Intelligence-driven Prediction Revealed CFTR Associated With Therapy Outcome Of Breast Cancer: A Feasibility Study. Oncology. 2024;102:1029–1040. doi: 10.1159/000540395. IF2023 = 2.5
  • Tesarova T, Fiala O, Hora M, Vaclavikova R. Non-coding transcriptome profiles in clear-cell renal cell carcinoma. Nat Rev Urol. 2024 Sep 6. doi: 10.1038/s41585-024-00926-3. IF2023 = 12.1
  • Sychra T, Spalenkova A, Balatka S, Vaclavikova R, Seborova K, Ehrlichova M, Truksa J, Sandoval-Acuña C, Nemcova V, Szabo A, Koci K, Tesarova T, Ojima I, Oliverius M, Soucek P. Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma. iScience 2024;27:109044. doi:10.1016/j.isci.2024.109044. IF2023 = 4.6
  • Ünal P, Lu Y, Bueno-de-Mesquita B, van Eijck CHJ, Talar-Wojnarowska R, Szentesi A, Gazouli M, Kreivenaite E, Tavano F, Małecka-Wojciesko E, Erőss B, Oliverius M, Bunduc S, Nóbrega Aoki M, Vodickova L, Boggi U, Giaccherini M, Kondrackiene J, Chammas R, Palmieri O, Theodoropoulos GE, Bijlsma MF, Basso D, Mohelnikova-Duchonova B, Soucek P, Izbicki JR, Kiudelis V, Vanella G, Arcidiacono PG, Włodarczyk B, Hackert T, Schöttker B, Uzunoglu FG, Bambi F, Goetz M, Hlavac V, Brenner H, Perri F, Carrara S, Landi S, Hegyi P, Dijk F, Maiello E, Capretti G, Testoni SGG, Petrone MC, Stocker H, Ermini S, Archibugi L, Gentiluomo M, Cavestro GM, Pezzilli R, Di Franco G, Milanetto AC, Sperti C, Neoptolemos JP, Morelli L, Vokacova K, Pasquali C, Lawlor RT, Bazzocchi F, Kupcinskas J, Capurso G, Campa D, Canzian F. Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk. Hum Genomics. 2024;18(1):12. doi: 10.1186/s40246-024-00576-x. IF2023 = 3.8
  • Holý P, Hlaváč V, Šeborová K, Šůsová S, Tesařová T, Rob L, Hruda M, Bouda J, Bartáková A, Mrhalová M, Kopečková K, Al Obeed Allah M, Špaček J, Sedláková I, Souček P, Václavíková R. Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression. Int J Cancer 2024; 155(1):104-116. doi:10.1002/ijc.34908. IF2023 = 5.7
  • Dvorak P, Hlavac V, Hanicinec V, Bhavana R, Soucek P. Genes divided according to the relative position of the longest intron show increased representation in different KEGG pathways. BMC Genomics, 2024;25(1):649. doi: 10.1186/s12864-024-10558-x. IF2023 = 3.5
  • Giaccherini M, Rende M, Gentiluomo M, Corradi C, Archibugi L, Ermini S, Maiello E, Morelli L, van Eijck CHJ, Cavestro GM, Schneider M, Mickevicius A, Adamonis K, Basso D, Hlavac V, Gioffreda D, Talar-Wojnarowska R, Schöttker B, Lovecek M, Vanella G, Gazouli M, Uno M, Malecka-Wojciesko E, Vodicka P, Goetz M, Bijlsma MF, Petrone MC, Bazzocchi F, Kiudelis M, Szentesi A, Carrara S, Nappo G, Brenner H, Milanetto AC, Soucek P, Katzke V, Peduzzi G, Rizzato C, Pasquali C, Chen X, Capurso G, Hackert T, Bueno-de-Mesquita B, Uzunoglu FGG, Hegyi P, Greenhalf W, Theodoropoulos GEE, Sperti C, Perri F, Oliverius M, Mambrini A, Tavano F, Farinella R, Arcidiacono PG, Lucchesi M, Bunduc S, Kupcinskas J, Di Franco G, Stocker S, Neoptolemos JP, Bambi F, Jamroziak K, Testoni SGG, Aoki MN, Mohelnikova-Duchonova B, Izbicki JR, Pezzilli R, Lawlor RT, Kauffmann EF, López de Maturana E, Malats N, Canzian F, Campa D. A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma. Mutagenesis. 2024 Apr 12:geae012. doi: 10.1093/mutage/geae012. Epub ahead of print. IF2023 = 2.5
  • Corradi C, Lencioni G, Felici A, Rizzato C, Gentiluomo M, Ermini S, Archibugi L, Mickevicius A, Lucchesi M, Malecka-Wojciesko E, Basso D, Arcidiacono PG, Petrone MC, Carrara S, Götz M, Bunduc S, Holleczek B, Aoki MN, Uzunoglu FG, Zanette DL, Mambrini A, Jamroziak K, Oliverius M, Lovecek M, Cavestro GM, Milanetto AC, Peduzzi G, Duchonova BM, Izbicki JR, Zalinkevicius R, Hlavac V, van Eijck CHJ, Brenner H, Vanella G, Vokacova K, Soucek P, Tavano F, Perri F, Capurso G, Hussein T, Kiudelis M, Kupcinskas J, Busch OR, Morelli L, Theodoropoulos GE, Testoni SGG, Adamonis K, Neoptolemos JP, Gazouli M, Pasquali C, Kormos Z, Skalicky P, Pezzilli R, Sperti C, Kauffmann E, Büchler MW, Schöttker B, Hegyi P, Capretti G, Lawlor RT, Canzian F, Campa D. Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk. Int J Cancer. 2024;155:1432-1442. doi: 10.1002/ijc.35046. Epub ahead of print. IF2023 = 5.7
  • Heczko L, Liška V, Vyčítal O, Fiala O, Šůsová S, Hlaváč V, Souček P. Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic signifikance. Hum Genomics, 2024;18:83. IF2023 = 3.8
    Kováčová M, Hlaváč V, Koževnikovová R, Rauš K, Gatěk J, Souček P. Artificial Intelligence-driven Prediction Revealed CFTR Associated With Therapy Outcome Of Breast Cancer: A Feasibility Study. Oncology. 2024;102:1029–1040. doi: 10.1159/000540395. IF2023 = 2.5
  • Dvorak P, Hanicinec V, Soucek P. The longest intron rule. Front Genetics 2023;13:1085139. doi: 10.3389/fgene.2022.1085139. IF = 2.7
  • Daniel P, Balušíková K, Václavíková R, Šeborová K, Ransdorfová Š, Valeriánová M, Wei L, Jelínek M, Tlapáková T, Fleischer T, Kristensen VN, Souček P, Ojima I, Kovář J. ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines. Genes (Basel). 2023;14(2):296. doi: 10.3390/genes14020296. IF = 2.8
  • Nodari Y, Gentiluomo M, Mohelnikova-Duchonova B, Kreivenaite E, Milanetto AC, Skieceviciene J, Landi S, Lawlor RT, Petrone MC, Arcidiacono PG, Lovecek M, Gazouli M, Bijlsma MF, Morelli L, Kiudelis V, Tacelli M, Zanette DL, Soucek P, Uzunoglu F, Kaaks R, Izbicki J, Boggi U, Pezzilli R, Mambrini A, Pasquali C, van Laarhoven HW, Katzke V, Cavestro GM, Sperti C, Loos M, Latiano A, Erőss B, Oliverius M, Johnson T, Basso D, Neoptolemos JP, Aoki MN, Greenhalf W, Vodicka P, Archibugi L, Vanella G, Lucchesi M, Talar-Wojnarowska R, Jamroziak K, Saeedi MA, van Eijck CHJ, Kupcinskas J, Hussein T, Puzzono M, Bunduc S, Götz M, Carrara S, Szentesi A, Tavano F, Moz S, Hegyi P, Luchini C, Capurso G, Perri F, Ermini S, Theodoropoulos G, Capretti G, Palmieri O, Ginocchi L, Furbetta N, Canzian F, Campa D. Genetic and non-genetic risk factors for early-onset pancreatic cancer. Dig Liver Dis. 2023; S1590-8658(23):00514-5. doi: 10.1016/j.dld.2023.02.023. IF = 4.0
  • Giaccherini M, Farinella R, Gentiluomo M, Mohelnikova-Duchonova B, Kauffmann EF, Palmeri M, Uzunoglu F, Soucek P, Petrauskas D, Cavestro GM, Zykus R, Carrara S, Pezzilli R, Puzzono M, Szentesi A, Neoptolemos J, Archibugi L, Palmieri O, Milanetto AC, Capurso G, van Eijck CHJ, Stocker H, Lawlor RT, Vodicka P, Lovecek M, Izbicki JR, Perri F, Kupcinskaite-Noreikiene R, Götz M, Kupcinskas J, Hussein T, Hegyi P, Busch OR, Hackert T, Mambrini A, Brenner H, Lucchesi M, Basso D, Tavano F, Schöttker B, Vanella G, Bunduc S, Petrányi Á, Landi S, Morelli L, Canzian F, Campa D. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk. Int J Cancer. 2023; 153(2):373-379. doi: 10.1002/ijc.34383. IF = 5.7
  • Hlaváč V, Červenková L, Šůsová S, Holý P, Liška V, Vyčítal O, Šorejs O, Fiala O, Daum O, Souček P. Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction. JCO Precision Oncol 2023; 7:e2200557. doi: 10.1200/PO.22.00557. IF = 5.3
    Alexander JL, Posma JM, Scott A, Poynter L, Mason SE, Doria ML, Herendi L, Roberts L, McDonald JAK, Cameron S, Hughes DJ, Liska V, Susova S, Soucek P, Horneffer-van der Sluis V, Gomez-Romero M, Lewis MR, Hoyles L, Woolston A, Cunningham D, Darzi A, Gerlinger M, Goldin R, Takats Z, Marchesi JR, Teare J, Kinross J. Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer. Microbiome 2023;11(1):100. doi: 10.1186/s40168-023-01518-w. IF = 13.8
  • Campa D, Gentiluomo M, Stein A, Aoki MN, Oliverius M, Vodičková L, Jamroziak K, Theodoropoulos G, Pasquali C, Greenhalf W, Arcidiacono PG, Uzunoglu F, Pezzilli R, Luchini C, Puzzono M, Loos M, Giaccherini M, Katzke V, Mambrini A, Kiudeliene E, Federico KE, Johansen J, Hussein T, Mohelnikova-Duchonova B, van Eijck CHJ, Brenner H, Farinella R, Pérez JS, Lovecek M, Büchler MW, Hlavac V, Izbicki JR, Hackert T, Chammas R, Zerbi A, Lawlor R, Felici A, Götz M, Capurso G, Ginocchi L, Gazouli M, Kupcinskas J, Cavestro GM, Vodicka P, Moz S, Neoptolemos JP, Kunovsky L, Bojesen SE, Carrara S, Gioffreda D, Morkunas E, Abian O, Bunduc S, Basso D, Boggi U, Wlodarczyk B, Szentesi A, Vanella G, Chen I, Bijlsma MF, Kiudelis V, Landi S, Schöttker B, Corradi C, Giese N, Kaaks R, Peduzzi G, Hegyi P, Morelli L, Furbetta N, Soucek P, Latiano A, Talar-Wojnarowska R, Lindgaard SC, Dijk F, Milanetto AC, Tavano F, Cervena K, Erőss B, Testoni SG, Verhagen-Oldenampsen JHE, Małecka-Wojciesko E, Costello E, Salvia R, Maiello E, Ermini S, Sperti C, Holleczek B, Perri F, Skieceviciene J, Archibugi L, Lucchesi M, Rizzato C, Canzian F. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years‘ experience of association studies to understand the genetic architecture of pancreatic cancer. Crit Rev Oncol Hematol. 2023;186:104020. doi: 10.1016/j.critrevonc.2023.104020. IF = 5.5
  • Flasarova D, Urban K, Strouhal O, Klos D, Lemstrova R, Dvorak P, Soucek P, Mohelnikova-Duchonova B. DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC. Int J Mol Sci. 2023;24:8868. doi: 10.3390/ijms24108868. IF = 4.9
  • Corradi C, Lencioni G, Gentiluomo M, Felici A, Latiano A, Kiudelis G, van Eijck CHJ, Marta K, Lawlor RT, Tavano F, Boggi U, Dijk F, Cavestro GM, Vermeulen RCH, Hackert T, Petrone MC, Uzunoğlu FG, Archibugi L, Izbicki JR, Morelli L, Zerbi A, Landi S, Stocker H, Talar-Wojnarowska R, Di Franco G, Hegyi P, Sperti C, Carrara S, Capurso G, Gazouli M, Brenner H, Bunduc S, Busch O, Perri F, Oliverius M, Hegyi PJ, Goetz M, Scognamiglio P, Mambrini A, Arcidiacono PG, Kreivenaite E, Kupcinskas J, Hussein T, Ermini S, Milanetto AC, Vodicka P, Kiudelis V, Hlaváč V, Soucek P, Theodoropoulos GE, Basso D, Neoptolemos JP, Nóbrega Aoki M, Pezzilli R, Pasquali C, Chammas R, Testoni SGG, Mohelnikova-Duchonova B, Lucchesi M, Rizzato C, Canzian F, Campa D. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma. J Med Genet. 2023; 60(10):980-986. doi: 10.1136/jmg-2022-108910. IF = 3.5
  • Spalenkova A, Ehrlichova M, Wei S, Guengerich FP, Soucek P. Effects of 7-ketocholesterol on tamoxifen efficacy in breast carcinoma cell line models in vitro. J Steroid Biochem Mol Biol. 2023;232:106354. doi: 10.1016/j.jsbmb.2023.106354. IF = 2.7
  • Piccardi M, Gentiluomo M, Bertoncini S, Pezzilli R, Erőss B, Bunduc S, Uzunoglu FG, Talar-Wojnarowska R, Vanagas T, Sperti C, Oliverius M, Aoki MN, Ermini S, Hussein T, Boggi U, Jamroziak K, Maiello E, Morelli L, Vodickova L, Di Franco G, Landi S, Szentesi A, Lovecek M, Puzzono M, Tavano F, van Laarhoven HWM, Zerbi A, Mohelnikova-Duchonova B, Stocker H, Costello E, Capurso G, Ginocchi L, Lawlor RT, Vanella G, Bazzocchi F, Izbicki JR, Latiano A, Bueno-de-Mesquita B, Ponz de Leon Pisani R, Schöttker B, Soucek P, Hegyi P, Gazouli M, Hackert T, Kupcinskas J, Poskiene L, Tacelli M, Roth S, Carrara S, Perri F, Hlavac V, Theodoropoulos GE, Busch OR, Mambrini A, van Eijck CHJ, Arcidiacono P, Scarpa A, Pasquali C, Basso D, Lucchesi M, Milanetto AC, Neoptolemos JP, Cavestro GM, Janciauskas D, Chen X, Chammas R, Goetz M, Brenner H, Archibugi L, Dannemann M, Canzian F, Tofanelli S, Campa D. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians. Biol Res. 2023;56(1):46. doi: 10.1186/s40659-023-00457-y. IF = 4.3
  • Holý P, Brynychová V, Šeborová K, Haničinec V, Koževnikovová R, Trnková M, Vrána D, Gatěk J, Kopečková K, Mrhalová M, Souček P. Integrative analysis of mRNA-miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer. Mol Oncol. 2023; 17(10):2074-2089. doi: 10.1002/1878-0261.13495. IF = 5.0
  • Tesarova T, Koucka K, Vaclavikova R, Seborova K, Hora M, Hes O, Pivovarcikova K, Soucek P, Fiala O. Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma. Oncol Lett. 2023;26(3):365. doi: 10.3892/ol.2023.13951. IF = 2.5
    Hlaváč V, Holý P, Souček P. The potential of exome sequencing of paired colorectal tumors and synchronous liver metastases to improve treatment. Pharmacogenomics. 2023; 24(13):697-699. doi: 10.2217/pgs-2023-0158. IF = 1.9
  • Červenková L, Palek R, Moulisova V, Liška V, Daum O, Mohelnikova-Duchonova B, Souček P. Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: prognostic role of ABCC8. Pancreatology 2023; 23(8): 978-987. doi: 10.1016/j.pan.2023. IF = 2.8
  • Galati L, Gupta P, Tufaro A, Marinaro M, Saponaro C, Escobar Marcillo DI, Loisi D, Sen R, Robitaille A, Brancaccio RN, Cuenin C, McKay-Chopin S, Paradiso AV, Liška V, Souček P, Zito FA, Hughes DJ, Tommasino M, Gheit T. Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples. Infect Agent Cancer. 2023;18(1):71. doi: 10.1186/s13027-023-00552-5. IF = 3.1
  • Heczko L, Hlaváč V, Holý P, Dvořák P, Liška V, Vyčítal O, Fiala O, Souček P. Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases. Cancer Cell Int 2023; 23:295. doi: 10.1186/s12935-023-03135-x. IF = 5.3
  • Giaccherini M, Gori L, Gentiluomo M, Farinella R, Cervena K, Skieceviciene J, Dijk F, Capurso G, Vezakis A, Archibugi L, Chammas R, Hussein T, Tavano F, Hegyi P, Lovecek M, Izbicki J, Brenner H, Mohelnikova-Duchonova B, Dell’Anna G, Kupcinskas J, Ermini S, Aoki MN, Neoptolemos JP, Gazouli M, Pasquali C, Pezzilli R, Talar-Wojnarowska R, Oliverius M, Al-Saeedi M, Lucchesi M, Furbetta N, Carrara S, van Eijck CHJ, Maleckas A, Milanetto AC, Lawlor RT, Schöttker B, Boggi U, Morelli L, Ginocchi L, Ponz de Leon R, Sperti C, Zerbi A, Arcidiacono PG, Uzunoglu FG, Bunduc S, Holleczek B, Gioffreda D, Małecka-Wojciesko E, Kiudelis M, Szentesi A, van Laarhoven HWM, Soucek P, Götz M, Erőss B, Cavestro GM, Basso D, Perri F, Landi S, Canzian F, Campa D. A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma. Carcinogenesis. 2023; 44(8-9):642-649. doi: 10.1093/carcin/bgad056. IF = 3.3

Historické – výběr
  • Šarmanová J, Benešová K, Gut I, Nedelcheva Kristensen V, Týnková L, Souček P. Genetic Polymorphisms of Biotransformation Enzymes in Patients with Hodgkin‘s and non-Hodgkin’s Lymphomas Hum. Mol. Genet., 2001;10:1265-1273. IF = 9.321.   
  • Souček P, Anzenbacher P, Skoumalová I, and Dvořák M. Expression of Cytochrome P450 Genes in CD34+ Hematopoietic Stem and Progenitor Cells. Stem Cells 2005;23: 1417-1422. IF = 6.09
  • Walsh T, Casadei S, Coats KH, Swisher E, Stray SM, Higgins J, Roach KC, Mandell J, Lee MK, Ciernikova S, Foretova L, Soucek P, King MC. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA 2006; 295(12):1379-88. IF = 23.17
  • Soucek P, Xenobiotics, In: Encyclopedia of Cancer, Schwab, M (Ed.), 2nd ed., 2008, Springer Verlag, 3235 pages.
  • Ueng YF, Chen CC, Chung YT, Liu TY, Chang YP, Lo WS, Murayama N, Yamazaki H, Souček P, Chau GY, Chi CW, Chen RM, Li DT. Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo. Br J Pharmacol 2011;163(6):1250-62. IF = 4.409
  • Hubackova M, Vaclavikova R, Ehrlichova M, Mrhalova, Kodet R, Kubackova K, Vrána D, Gut I, Soucek P. Association of superoxide dismutases and NAD(P)H oxidoreductases with prognosis of patients with breast carcinomas. Int J Cancer 2012;130(2):338-348. IF = 6.198
  • Wolpin BM, Rizzato C, Kraft P, Kooperberg C, Petersen GM, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Buring J, Canzian F, Duell EJ, Gallinger S, Giles GG, Goodman GE, Goodman PJ, Jacobs EJ, Kamineni A, Klein AP, Kolonel LN, Kulke MH, Li D, Malats N, Olson SH, Risch HA, Sesso HD, Visvanathan K, White E, Zheng W, Abnet CC, Albanes D, Andreotti G, Austin MA, Barfield R, Basso D, Berndt SI, Boutron-Ruault MC, Brotzman M, Büchler MW, Bueno-de-Mesquita HB, Bugert P, Burdette L, Campa D, Caporaso NE, Capurso G, Chung C, Cotterchio M, Costello E, Elena J, Funel N, Gaziano JM, Giese NA, Giovannucci EL, Goggins M, Gorman MJ, Gross M, Haiman CA, Hassan M, Helzlsouer KJ, Henderson BE, Holly EA, Hu N, Hunter DJ, Innocenti F, Jenab M, Kaaks R, Key TJ, Khaw KT, Klein EA, Kogevinas M, Krogh V, Kupcinskas J, Kurtz RC, LaCroix A, Landi MT, Landi S, Le Marchand L, Mambrini A, Mannisto S, Milne RL, Nakamura Y, Oberg AL, Owzar K, Patel AV, Peeters PH, Peters U, Pezzilli R, Piepoli A, Porta M, Real FX, Riboli E, Rothman N, Scarpa A, Shu XO, Silverman DT, Soucek P, Sund M, Talar-Wojnarowska R, Taylor PR, Theodoropoulos GE, Thornquist M, Tjønneland A, Tobias GS, Trichopoulos D, Vodicka P, Wactawski-Wende J, Wentzensen N, Wu C, Yu H, Yu K, Zeleniuch-Jacquotte A, Hoover R, Hartge P, Fuchs C, Chanock SJ, Stolzenberg-Solomon RS, Amundadottir LT. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet. 2014; 46(9):994-1000. IF = 29.352
  • Kloudova A, Guengerich FP, Soucek P. The role of oxysterols in human cancer. Trends Endocrinol Metab. 2017; 28(7): 485-496. IF = 10.769
  • Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E, Zhang M, Canzian F, Childs EJ, Hoskins JW, Jermusyk A, Zhong J, Chen F, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt SI, Blackford A, Borges M, Borgida A, Bracci PM, Brais L, Brennan P, Brenner H, Bueno-de-Mesquita B, Buring J, Campa D, Capurso G, Cavestro GM, Chaffee KG, Chung CC, Cleary S, Cotterchio M, Dijk F, Duell EJ, Foretova L, Fuchs C, Funel N, Gallinger S, M Gaziano JM, Gazouli M, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Hackert T, Haiman C, Hartge P, Hasan M, Hegyi P, Helzlsouer KJ, Herman J, Holcatova I, Holly EA, Hoover R, Hung RJ, Jacobs EJ, Jamroziak K, Janout V, Kaaks R, Khaw KT, Klein EA, Kogevinas M, Kooperberg C, Kulke MH, Kupcinskas J, Kurtz RJ, Laheru D, Landi S, Lawlor RT, Lee IM, LeMarchand L, Lu L, Malats N, Mambrini A, Mannisto S, Milne RL, Mohelníková-Duchoňová B, Neale RE, Neoptolemos JP, Oberg AL, Olson SH, Orlow I, Pasquali C, Patel AV, Peters U, Pezzilli R, Porta M, Real FX, Rothman N, Scelo G, Sesso HD, Severi G, Shu XO, Silverman D, Smith JP, Soucek P, Sund M, Talar-Wojnarowska R, Tavano F, Thornquist MD, Tobias GS, Van Den Eeden SK, Vashist Y, Visvanathan K, Vodicka P, Wactawski-Wende J, Wang Z, Wentzensen N, White E, Yu H, Yu K, Zeleniuch-Jacquotte A, Zheng W, Kraft P, Li D, Chanock S, Obazee O, Petersen GM, Amundadottir LT. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nat Commun. 2018;9(1):556. IF = 11.878
  • Bleach R, Madden SF, Hawley J, Charmsaz S, Selli C, Sheehan KM, Young LS, Sims AH, Soucek P, Hill AD, McIlroy M. Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy. Clin Cancer Res. 2021; 27(14):3980-3989. doi: 10.1158/1078-0432.CCR-20-4135. IF = 13.801Kloudova-Spalenkova A, Holy P, Soucek P. Oxysterols in Cancer Management: From Therapy to Biomarkers. Brit J Pharmacol. 2021;178:3235–3247. doi: 10.1111/bph.15273. IF = 9.479

Zahraniční spolupráce

  • Prof. F. Peter Guengerich, Ph.D. – Center in Molecular Toxicology, Medical School, Vanderbilt University, Nashville, TN, USA
  • Prof. Iwao Ojima, Ph.D. – Institute of Chemical Biology & Drug Discovery, State University of New York at Stony Brook, Stony Brook, NY, USA
  • Prof. Elizabeth M. Gillam, Ph.D. – School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
  • Yune-Fang Ueng, Ph.D. – National Research Institute of Chinese Medicine, Taipei, Taiwan
  • Prof. Vessela N. Kristensen, Ph.D. – Institute for Clinical Epidemiology and Molecular Biology (EpiGen), Faculty of Medicine, University of Oslo and Group of Cancer Genome Variation Department of Genetics, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet, Oslo, Norway
  • David Hughes, Ph.D. – Department of Physiology & Medical Physics & Centre for Systems Medicine, Royal College of Surgeons Ireland, Dublin, Ireland
  • Federico Canzian, Ph.D. – German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Prof. Daniele Campa, Ph.D. – Department of Biology, University of Pisa, Pisa, Italy
  • Assist. Prof. Felix Dietlein, M.D., Ph.D. – Boston Children’s Hospital, Harvard Medical School, Dana-Farber Cancer Institute, Broad Institute of MIT and Harvard, Boston, USA

Probíhající grantové projekty

  • 2025–2028, AZV No. NW25-03-00150: Biocompatible nanomedicines with tuned pharmacokinetics for advanced treatment of pancreatic carcinoma
  • 2025–2027, Charles University, PRIMUS/25/MED/007: The role of circular RNAs in chemotherapy resistance in colorectal cancer
  • 2024–2027, AZV No. NW24-03-00024: Predictive and prognostic factors for an individualized strategy of pancreatic cancer diagnosis and therapy
  • 2024–2027, AZV No. NU24-09-00505: Molecular classification in relation to prevention of endometrial cancer recurrence and lifestyle factors
  • 2023-2027, MEYS LUAUS 23164: Targeted taxane derivatives as potential therapeutic possibility in the treatment of resistant and highly aggressive forms of tumors
  • 2023-2025, GA ČR 23-05609S: Explaining metastatic potential of colorectal cancer through whole-exome sequencing and immune cell and telomere landscape
  • 2022-2025, EU-MŠMT Programme EXCELES, ID Project No. LX22NPO5102: National Institute for Cancer Research 
  • 2022–2025, AZV No. NU22-08-00186: Integromics concept in prediction of ovarian cancer therapy outcome and new therapeutic target identification
  • 2022–2025, AZV No. NU22-08-00281: Multiomics for discovery of biomarkers for breast cancer resistance prediction
  • 2022–2025, Charles University, project Cooperatio – Surgical Disciplines No. 207043
  • 2021–2024, GAČR No. 21-27902S: Telomere homeostasis from colorectal adenoma to metastatic cancer

Kontakt

prof. RNDr. Pavel Souček, CSc.
T: 377 593 840 | 267 082 711
E: pavel.soucek@lfp.cuni.cz