{"id":3370,"date":"2025-01-03T13:22:48","date_gmt":"2025-01-03T12:22:48","guid":{"rendered":"https:\/\/biomedic.lfp.cuni.cz\/?page_id=3370"},"modified":"2026-01-27T09:50:37","modified_gmt":"2026-01-27T08:50:37","slug":"laboratory-of-reproductive-medicine","status":"publish","type":"page","link":"https:\/\/biomedic.lfp.cuni.cz\/en\/faculty\/laboratory-of-reproductive-medicine\/","title":{"rendered":"Laboratory of Reproductive Medicine"},"content":{"rendered":"\n<p><a href=\"https:\/\/biomedic.lfp.cuni.cz\/wp-admin\/edit.php?post_type=page\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"2560\" height=\"380\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/Navrh-bez-nazvu-19.png\" alt=\"\" class=\"wp-image-3926\" srcset=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/Navrh-bez-nazvu-19.png 2560w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/Navrh-bez-nazvu-19-900x134.png 900w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/Navrh-bez-nazvu-19-1400x208.png 1400w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/Navrh-bez-nazvu-19-1800x267.png 1800w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h1 class=\"wp-block-heading\">Laboratory of Reproductive Medicine<\/h1>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Lab events<\/h2>\n\n\n    <section class=\"block block-post-listing-dynamic\" >\n                <div id=\"ajax-load-more\" class=\"ajax-load-more-wrap default\" data-id=\"posts\" data-alm-id=\"\" data-canonical-url=\"https:\/\/biomedic.lfp.cuni.cz\/en\/faculty\/laboratory-of-reproductive-medicine\/\" data-slug=\"laboratory-of-reproductive-medicine\" data-post-id=\"3370\"  data-localized=\"ajax_load_more_posts_vars\" data-alm-object=\"ajax_load_more_posts\"><div aria-live=\"polite\" aria-atomic=\"true\" class=\"alm-listing alm-ajax\" data-cache=\"true\" data-preloaded=\"true\" data-preloaded-amount=\"2\" data-container-type=\"div\" data-loading-style=\"default\" data-theme-repeater=\"post.php\" data-post-type=\"post\" data-taxonomy=\"category\" data-taxonomy-terms=\"laboratory-of-reproductive-medicine\" data-taxonomy-relation=\"OR\" data-order=\"DESC\" data-orderby=\"date\" data-offset=\"0\" data-posts-per-page=\"2\" data-lang=\"en\" data-scroll=\"false\" data-pause=\"true\" data-button-label=\"Show more\" data-button-done-label=\"All posts loaded\" data-prev-button-label=\"Load Previous\">\t\t<article class=\"post\">\n            <div class=\"picture\">\n            <a href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/aktuality-en\/vikendova-skola-aplikovane-embryologie\/\">\n                                <img decoding=\"async\" width=\"328\" height=\"216\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2026\/04\/Symposium-Aplikovana-Embryologie-6-900x400-1-328x216.webp\" class=\"thumbnail wp-post-image\" alt=\"V\u00edkendov\u00e1 \u0161kola Aplikovan\u00e9 embryologie\" \/>            <\/a>\n        <\/div>\n        <div class=\"content\">\n        <h3><a href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/aktuality-en\/vikendova-skola-aplikovane-embryologie\/\">V\u00edkendov\u00e1 \u0161kola Aplikovan\u00e9 embryologie<\/a><\/h3>\n                    <div class=\"excerpt auto\">\n                \n18. 4. 2026 8:00\u201316:00 Zelen\u00e1 posluch\u00e1rna\n\n\n\n            <\/div>\n                <a class=\"icon arrow-right\" href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/aktuality-en\/vikendova-skola-aplikovane-embryologie\/\">More<\/a>\n    <\/div>\n<\/article>\t\t\t<article class=\"post\">\n            <div class=\"picture\">\n            <a href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/laboratory-of-reproductive-medicine\/summer-school-of-applied-embryology\/\">\n                                <img decoding=\"async\" width=\"328\" height=\"216\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/08\/Letni_skola_embryologie-328x216.png\" class=\"thumbnail wp-post-image\" alt=\"Summer School of Applied Embryology\" srcset=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/08\/Letni_skola_embryologie-328x216.png 328w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/08\/Letni_skola_embryologie-656x432.png 656w\" sizes=\"(max-width: 328px) 100vw, 328px\" \/>            <\/a>\n        <\/div>\n        <div class=\"content\">\n        <h3><a href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/laboratory-of-reproductive-medicine\/summer-school-of-applied-embryology\/\">Summer School of Applied Embryology<\/a><\/h3>\n                    <div class=\"excerpt auto\">\n                            <\/div>\n                <a class=\"icon arrow-right\" href=\"https:\/\/biomedic.lfp.cuni.cz\/en\/laboratory-of-reproductive-medicine\/summer-school-of-applied-embryology\/\">More<\/a>\n    <\/div>\n<\/article>\t<\/div><div class=\"alm-btn-wrap\" data-rel=\"ajax-load-more\"><button class=\"alm-load-more-btn \" type=\"button\">Show more<\/button><\/div><div class=\"alm-no-results\" style=\"display: none;\"><p class='notice'>We are really sorry but there are no posts.<\/p><\/div><\/div>    <\/section>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-default\" \/>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group condensed\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Research Projects<\/h2>\n\n\n\n<div class=\"wp-block-columns margin-bottom-32 margin-top-64 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image size-medium-fixed element\"><img decoding=\"async\" width=\"555\" height=\"352\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/blastocysta2b-555x352.jpg\" alt=\"\" class=\"wp-image-3967\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong>Epigenetics<\/strong><\/h2>\n\n\n\n<p>Histone deacetylase SIRT1 regulates early embryonic development through the epigenetic and non-epigenetic modes of action.<\/p>\n\n\n\n<p>The most recent paper about SIRT1 across mammalian species: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39285243\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39285243\/\">Nevoral et al., 2024<\/a><\/p>\n\n\n\n<p><strong>Cooperating partners in France and Slovakia<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns margin-bottom-32 margin-top-32 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.inrae.fr\/en\/centres\/ile-france-jouy-josas-antony\"><img decoding=\"async\" width=\"106\" height=\"146\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo.png\" alt=\"\" class=\"wp-image-3879\" style=\"width:85px;height:auto\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"293\" height=\"160\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo-ukf-EN.png\" alt=\"\" class=\"wp-image-3881\" style=\"width:161px;height:auto\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image size-medium-fixed element\"><img decoding=\"async\" width=\"555\" height=\"352\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/spermie-555x352.png\" alt=\"\" class=\"wp-image-3908\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><strong>Hydrogen sulfide<\/strong><\/strong><\/h2>\n\n\n\n<p>This gasotransmitter acts as a second messenger, modifying proteins post-translationally, particularly in transcriptionally silenced gametes. <\/p>\n\n\n\n<p>We have recognized hydrogen sulfide signal molecule modulating sperm surface signature: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35794129\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35794129\/\">\u0158imn\u00e1\u010dov\u00e1 et al., 2022<\/a><\/p>\n\n\n\n<p><strong>Cooperating partners in Spain and South Korea<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns margin-bottom-32 margin-top-32 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.uclm.es\/?sc_lang=en\"><img decoding=\"async\" width=\"1557\" height=\"465\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo_uclm_en.png\" alt=\"\" class=\"wp-image-3902\" style=\"width:154px;height:auto\" srcset=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo_uclm_en.png 1557w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo_uclm_en-900x269.png 900w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo_uclm_en-1400x418.png 1400w\" sizes=\"(max-width: 1557px) 100vw, 1557px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.jbnu.ac.kr\/promo\/intro\/introduction.do\"><img decoding=\"async\" width=\"162\" height=\"40\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/logo_black.png\" alt=\"\" class=\"wp-image-3904\" style=\"width:161px;height:auto\" \/><\/a><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group condensed\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns margin-bottom-64 margin-top-32 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image size-medium-fixed element\"><img decoding=\"async\" width=\"555\" height=\"352\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/mito_dedicnost_2-2-555x352.jpg\" alt=\"\" class=\"wp-image-3971\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong>Mitochondria<\/strong><\/h2>\n\n\n\n<p>Oocytes carry a cytoplasmic genome housed in mitochondrial DNA, silenced till the late blastocyst.<\/p>\n\n\n\n<p>We presented the idea of risky transmission of mitochondrial mutations to offspring: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37159849\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37159849\/\">Shavit et al., 2023<\/a><\/p>\n\n\n\n<p><strong>Partners in USA<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns margin-bottom-32 margin-top-32 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/cafnrfaculty.missouri.edu\/sutovskylab\/\"><img decoding=\"async\" width=\"500\" height=\"281\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/University-of-Missouri-Logo-500x281-1.png\" alt=\"\" class=\"wp-image-3914\" style=\"width:174px;height:auto\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image size-medium-fixed element\"><img decoding=\"async\" width=\"555\" height=\"352\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/01\/IMG_7036-555x352.jpg\" alt=\"\" class=\"wp-image-3458\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong>Contact<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/is.cuni.cz\/webapps\/whois2\/osoba\/1367834050003269\/?lang=en\">Jan Nevoral, Ph.D.<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:37px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/orcid.org\/0000-0002-2048-7325\" target=\"_blank\" rel=\"noreferrer noopener\">ORCID<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n<\/div><\/div>\n\n\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Our <strong>Team<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1400\" height=\"1165\" src=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/eIMG_0531_6D-1-1400x1165.jpg\" alt=\"\" class=\"wp-image-3938\" srcset=\"https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/eIMG_0531_6D-1-1400x1165.jpg 1400w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/eIMG_0531_6D-1-900x749.jpg 900w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/eIMG_0531_6D-1-1800x1498.jpg 1800w, https:\/\/biomedic.lfp.cuni.cz\/wp-content\/uploads\/sites\/5\/2025\/03\/eIMG_0531_6D-1.jpg 1920w\" sizes=\"(max-width: 1400px) 100vw, 1400px\" \/><\/figure>\n\n\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>Jan NEVORAL, Ph.D., group leader<\/li>\n\n\n\n<li>Filip TIRP\u00c1K, Ph.D., postdoctoral researcher<\/li>\n\n\n\n<li>Kate\u0159ina GRYGAROV\u00c1, graduate student<\/li>\n\n\n\n<li>V\u011bra VT\u00cdPILOV\u00c1, graduate student<\/li>\n\n\n\n<li>Gabriela P\u0158IB\u00c1\u0147OV\u00c1, technician<\/li>\n\n\n\n<li>Eva KRALOVCOV\u00c1, technician<\/li>\n\n\n\n<li>V\u00e1clav R\u00da\u010cKA, technician<\/li>\n\n\n\n<li>Krist\u00fdna POPELKOV\u00c1, technician<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Laboratory of Reproductive Medicine Lab events Research Projects Epigenetics Histone deacetylase SIRT1 regulates early embryonic development through the epigenetic and non-epigenetic modes of action. The most recent paper about SIRT1&#8230;<\/p>\n","protected":false},"author":1,"featured_media":3458,"parent":3368,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"coauthors":[83,116,126,134],"class_list":["post-3370","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/pages\/3370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/comments?post=3370"}],"version-history":[{"count":51,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/pages\/3370\/revisions"}],"predecessor-version":[{"id":4458,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/pages\/3370\/revisions\/4458"}],"up":[{"embeddable":true,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/pages\/3368"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/media\/3458"}],"wp:attachment":[{"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/media?parent=3370"}],"wp:term":[{"taxonomy":"author","embeddable":true,"href":"https:\/\/biomedic.lfp.cuni.cz\/en\/wp-json\/wp\/v2\/coauthors?post=3370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}