Laboratory of Reproductive Medicine

Lab Events

Weekend School of Applied Embryology, 2025

Summer School of Applied Embryology, 2024


News


Research Projects

Epigenetics

Histone deacetylase SIRT1 regulates early embryonic development through the epigenetic and non-epigenetic modes of action.

The most recent paper about SIRT1 across mammalian species: Nevoral et al., 2024

Cooperating partners in France and Slovakia

Hydrogen sulfide

This gasotransmitter acts as a second messenger, modifying proteins post-translationally, particularly in transcriptionally silenced gametes.

We have recognized hydrogen sulfide signal molecule modulating sperm surface signature: Řimnáčová et al., 2022

Cooperating partners in Spain and South Korea

Mitochondria

Oocytes carry a cytoplasmic genome housed in mitochondrial DNA, silenced till the late blastocyst.

We presented the idea of risky transmission of mitochondrial mutations to offspring: Shavit et al., 2023

Partners in USA


Our Team

  • Jan NEVORAL, Ph.D., group leader
  • Miki SHAVIT, graduate student
  • Kateřina GRYGAROVÁ, graduate student
  • Věra VTÍPILOVÁ, graduate student
  • Gabriela PŘIBÁŇOVÁ, technician
  • Eva KRALOVCOVÁ, technician
  • Václav RÚČKA, technician
  • Kristýna POPELKOVÁ, technician
  • Štěpánka JANSOVÁ, technician