Laboratory of Reproductive Medicine

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Histone deacetylase SIRT1 regulates early embryonic development through the epigenetic and non-epigenetic modes of action.

The most recent paper about SIRT1 across mammalian species: Nevoral et al., 2024

Cooperating partners in France and Slovakia

This gasotransmitter acts as a second messenger, modifying proteins post-translationally, particularly in transcriptionally silenced gametes.

We have recognized hydrogen sulfide signal molecule modulating sperm surface signature: Řimnáčová et al., 2022

Cooperating partners in Spain and South Korea

Oocytes carry a cytoplasmic genome housed in mitochondrial DNA, silenced till the late blastocyst.

We presented the idea of risky transmission of mitochondrial mutations to offspring: Shavit et al., 2023

Partners in USA

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